LDL helps convey LPS out of the body, one reason why low LDL can raise the risk of serious infection. If we define the term “root cause” as the main cause that contributes early in the cascade of biological events leading to disease, then insulin resistance is clearly a root cause of type 2 diabetes. Virtually all people destined to develop type 2 diabetes will first become insulin resistant and it is considered one of two necessary causal factors in this disease (the other being failure of the cells that produce insulin, beta cells). A runny nose, scratchy throat, and nonstop sneezing -- you can't miss the signs of a cold. But mystery shrouds a lot of other things about it. Why do you seem to get them so often while your best friend stays well? And more importantly, how can you stay healthy this year? Get the lowdown on the all-too-common common cold. What Is It? IR tends to increase with age, including postmenopausal with lower estrogen, as well as lower testosterone.

Why do they strike in winter? - Medical News Today Colds and flu: Why do they strike in winter? - Medical News Today

This reference scored 2 as it convincingly supports one part of the claim (that insulin resistance and high pressure are related) but not the other (that almost all people with hypertension are insulin resistant). The study is a post-hoc analysis of insulin sensitivity and hypertension from the prospective Insulin Resistance Atherosclerosis Study—an observational study designed to assess the relationships between insulin resistance, insulinemia, glycemia, and other components of cardiovascular disease in 1,600 adults. It found the risk of developing incident hypertension over 2 – 5 years was 11% lower for every unit increase in insulin sensitivity. This effect corresponded with the most insulin sensitive group having a 33% lower risk of developing hypertension compared to the least insulin sensitive group. Trade-offs. Evolution does not occur in a vacuum. Changes in one trait that are beneficial can have resulting costs, and can be balanced by negative effects elsewhere. This is what we call a trade-off. For example, individuals with higher blood pressure may have greater exercise ability, but at the cost of damage to the tissues in later years. Another example is humans losing most of the hair (fur) that covers skin in most other primates. This enables better cooling of the body, and the ability to chase animals over long distances without overheating. There are downsides however, including increased exposure to the harmful UV rays in sunlight that can cause skin cancer. In evolution, nothing is perfect; all changes that bring benefits also have costs. The DiRECT trial, in particular, showed that 86.1% of type 2 diabetics achieved remission if they lost 15 kg of their body weight or more at 12 months. In fact, weight loss was the only strong predictor of type 2 diabetes remission in this clinical trial, whereas fasting insulin levels did not predict remission. Long-term studies of weight loss ( bariatric) surgery have reached similar conclusions; glucose control improves within days of surgery due to preferential and rapid mobilization of fat from the liver and pancreas. During winter, levels of UV radiation are much lower than in summer. This has a direct effect on how much vitamin D our bodies can make.Stress is a part of everyday life for most people. However, chronic stress persists over time and can adversely affect health.

Book Summary: “Why We Get Sick”, by Ben Bikman PhD

IR is extremely common, at least half of American adults have it, and possibly more like 88%. It’s also very common in other developed nations. IR is probably also a major contributor to earlier and earlier puberty, as fat storage and leptin send signals to start puberty. Oddly, undernourished babies are also more likely to become obese (like in the Dutch famine study).Avoid the temptation to restrict protein, even on a ketogenic diet. 1 – 1.5 g per kg body weight is decent, but you probably need more as you get older. It is clear that both the ubiquitous natural and artificial toxins are threats to our health. So can we count on the development of modern civilization to counter the ill effect of these toxins? The answer may surprise you. The rapidly developing modern civilization, on the contrary, poses a significant threat to our health.

Why We Get Sick - Google Books

Another example of a disease spread due to our developing civilization is the flu that threatens human health. In the course of globalization, people with flu on international flights will unknowingly spread the flu virus, making the flu a common threat to people all over the world. But if you understand what causes IR, and how to fix it…you’ll have a better chance of avoiding those diseases and living a healthy, productive life. Other temperate locations across the globe see similar patterns, with cold temperatures and low humidity being the prime factors, according to one 2013 analysis. The same cannot be said for tropical areas, however. I took pretty detailed notes as I was reading, so I thought I would share them in case anyone finds it useful.(I also added a much shorter summary to my book list.)Chronic/Noninfectious Disease." Minnesota Department of Health: Strategies for Public Health. 2002. (March 5, 2010)http://www.health.state.mn.us/strategies/chronic.pdf Please note that 2 of the references scored a 1 because the reference seemed so detached from the claim that we believe there was a citation error. The intended reference may be elsewhere in the book but we decided not to seek it on both occasions. The book’s primary goal is to spread awareness of insulin resistance and outline evidence-based lifestyle changes to manage it. These lifestyle recommendations include following a low-carbohydrate diet, restricting a specific type of fat called omega-6, exercising regularly, not smoking, and fasting intermittently. A scientist reveals the groundbreaking evidence linking many major diseases, including cancer, diabetes, and Alzheimer’s disease, to a common root cause—insulin resistance—and shares an easy, effective plan to reverse and prevent it.